Expert Opinion: Omega-3 fatty acids and bleedingCause for concern? Learn more about the link. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. apple juice), Not allowed as clear liquid: Milk, milk products or, No clear liquids within 2 hours of surgery, Includes orange juice, soda, infant formula and milk, No fried foods, fatty foods or meats within 8 hours of surgery, Exceptions - cardiovascular medications to stop, Risk of withdrawal when abruptly stopped perioperatively, Despite case reports of infection and delayed healing risks, Oral diabetes medications are typically held on the day of surgery (see below), Medications associated with bleeding risk, Short-acting agents: Stop 1 day before surgery, Mid-acting agents: Stop 3 days before surgery, Long-acting agents: Stop 10 days before surgery, Do not stop antiplatelet agents without carefully reviewing indications and minimum duration from stenting, Cardiology should be consulted before stopping P2Y agents in post-stenting patients, Stop at least 5 days before surgery if no contraindication to stopping, Stop at least 7 days before surgery if no contraindication to stopping, Restart 24 hours after procedure or per surgeons discretion, Patients with high thrombosis risk (e.g. I was diagnosed with AFIB about 4 years ago. While more clinical studies need to be done with larger sample sizes, these initial findings are promising. Vascepa (icosapent ethyl) capsules are the first FDA approved EPA only Omega-3 fatty acid. But new medications can help lower cholesterol and improve heart health. Vascepa (icosapent ethyl). should i stop vascepa before surgery. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Factors to consider include those in the list below. Limiting heavy foods and avoiding big meals can help you feel better before and after the procedure. Also, arrange for children or family members who require supervision to stay at home during your surgery. Stop clopidogrel five . (2018). Circulation: Cardiovascular Quality and Outcomes, 11(11):e004584. Vascepa contains the active ingredient* icosapent ethyl, which is a modified form of an omega-3 fatty acid called eicosapentaenoic acid (EPA). Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. For most people who are taking Coumadin (Warfarin) for chronic heart rhythm problems (like atrial fibrillation) it is usually safe to stop it for four (4) days prior to the procedure. For more information about the drugs dosage, see the What is Vascepas dosage? section above. Rules about when to stop eating and drinking are created to keep patients safe! -As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in adult patients with triglyceride levels of 150 mg/dL or higher and established cardiovascular disease or diabetes mellitus and 2 or more additional risk factors for cardiovascular disease. No, Vascepa isnt fish oil. Starting from the day of their surgery until their release from hospital, the omega-3 group continued to take 1.7g of EPA/DHA. If you think your liver function is getting worse during treatment, talk with your doctor immediately. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Before you take Vascepa, tell your doctor if you have liver disease, diabetes, a thyroid disorder, pancreas problems, a bleeding or blood-clotting disorder, an allergy to fish or shellfish, or if you drink large quantities of alcohol. Learn how B vitamins such as biotin, niacin and riboflavin, as well as calcium supplements, St. John's wort, vitamin C, and others supplements can affect test results, as well as common foods that may interfere with tests. Search Bing for all related images, Preoperative Guidelines for Medications Prior to Surgery, Nothing by Mouth Prior to Surgery Guideline, Medication Management in the Perioperative Period, Preoperative Evaluation in Kidney Disease, Antiplatelet Therapy for Vascular Disease, Postoperative Nausea and Vomiting Prevention, Protocol: Medications to still take on morning of surgery, Protocol: Medications to not take on morning of surgery, Protocol: Medications to avoid in the perioperative period, (2011) Anesthesiology 114: 495511 [PubMed], Wallace (2006) Curr Opin Anaesthesiol 19(4):411-7 +PMID:16829723 [PubMed], Warfarin Protocol for the Perioperative Period, Comfere (2005) Anesth Analg 100:636-44 [PubMed], den Broeder (2007) J Rheumatol 34(4):689-95 [PubMed], (2012) Anesthesiology 116:522-38 [PubMed], Search other sites for 'Preoperative Guidelines for Medications Prior to Surgery', Rule: 2, 4, 6, 8 rule applies to all ages, Fruit juice without pulp (e.g. should i stop vascepa before surgery. no LMWH for 12-24 hours prior to surgery Or Commence IV unfractionated heparin when INR <2. However, if it is only a few hours until your next dose, do not double the dose, just go back to your regular dosing schedule. A 2018 study co-authored by Dr. William Harris also investigated the risk of bleeding during cardiac surgeries. Clinical Nutrition, 37(3):948-957. If you're going to have surgery, you may need to stop taking your aspirin 1 week beforehand. Reduce your alcohol intake. This is not the case with Vascepa because it is not a fish oil. Aka: Preoperative Guidelines for Medications Prior to Surgery, Preoperative Fasting Recommendation, Nothing by Mouth Prior to Surgery Guideline, Perioperative NPO Guidelines, Perioperative Medication Guidelines, Medication Management in the Perioperative Period, Medications to Avoid Prior to Surgery, These images are a random sampling from a Bing search on the term "Preoperative Guidelines for Medications Prior to Surgery." Medically reviewed by Carmen Fookes, BPharm. Or go to the nearest emergency room. This risk occurred more often in people taking medications for preventing blood clots, such as warfarin (Jantoven), aspirin, or clopidogrel (Plavix). You can also check out this article to learn more about saving money on prescriptions. Common medications that may interact with Vascepa include: In general, any medicine that can increase the risk of bleeding (such as clopidogrel, SSRI antidepressants [eg, citalopram, duloxetine, fluoxetine, venlafaxine], fish oils) may interact with Vascepa. Vascepa is a prescription medication used to: help lower blood levels of triglycerides in adults with certain conditions help lower the risk of heart problems in certain people Vascepa is not. This is not the case with Vascepa, because it is not a fish oil. Find out which vitamins and supplements can interfere with blood, urine or stool tests, and imaginging tests. Categories large black pillows for couch; Posted by ; car phone holder charger iphone . It may also be called an omega-3 fatty acid. <>>> 6.2 Postmarketing Experience If you have an allergic reaction to Vascepa, talk with your doctor immediately. Take Vascepa capsules whole. Icosapent ethyl is used along with certain other cholesterol medications ("statins" such as atorvastatin, simvastatin) to reduce the risk of heart attack, stroke, and certain types of heart. Unsaturated fats and oils from plants and fish bring down triglycerides. It is not known whether Vascepa will lower your risk of pancreatitis (inflammation of your pancreas). You may report side effects to FDA at 1-800-FDA-1088. There are no documented reports that Vascepa helps with weight loss. (2016). Light to moderate alcohol consumption may lower the amount of triglycerides in your blood. Dr. William Kennedy a leading US orthopedic surgeon explains that constipation often results in rising body temperatures, leading many overseeing physicians to believe that their patient is experiencing an infection. Can I take both fish oil supplements and Vascepa? Because omega-3 fish oil and cod liver oils have a noted blood thinning effect, it was long believed that consuming these kinds of oils could increase a patients risk of bleeding during an operation. (3Pl!3LZNhAz@'XgH^57- Ws %xBA Bu Serious side effects from Vascepa can occur, but they arent common. While gearing up for surgery, your surgeon will probably give you a list of medications -- both prescription and over-the-counter -- that you'll need to stop beforehand. Avoid alcohol for 48 hours before surgery. Find answers to some commonly asked questions about Vascepa. Also, describe any vitamins, herbs, or supplements you use. The medications listed below (and potentially many others) may have an effect on your blood's ability to coagulate. 3 0 obj What are some frequently asked questions about Vascepa? And, By now youve probably heard of the many benefits of omega-3 fatty acids for a, Vitamin D has made headlines many times these last few years of the pandemic. It contains the active ingredient icosapent ethyl, which is a kind of omega-3 fatty acid. Last dose prior to surgery given in morning, the day BEFORE surgery i.e. The most common causes of high triglycerides are obesity, high carbohydrate or high-sugar diets, excessive alcohol intake, physical inactivity, and poorly controlled diabetes. The daily dose of VASCEPA is 4 grams per day taken as either: . In a 2018 meta-analysis, researchers demonstrated a connection between omega-3s and lowered anxiety in patients with a clinical diagnosis with the caveat that the patients needed an effective omega-3 dose to get results (11). Generics usually cost less than brand-name drugs. -As an adjunct to diet to reduce triglyceride (TG) levels in patients with severe (500 mg/dL or greater) hypertriglyceridemia. Kaliannan, K. et al. It is very important for every patient to have an empty stomach before any surgery or procedure that requires anesthesia, for two reasons: To prevent nausea To keep any food or liquid from getting into the lungs. Generic name: icosapent [eye-KOE-sa-pent] Restlessness or anxiety. (2018). Follow all directions on your prescription label and read all medication guides or instruction sheets. Review your medication list, with recommendations for how to take your medications prior to surgery. Every physician has their own pre-operative and post-operative instructions I don't recall any of my physicians suggesting that I stop taking pre-workout supplements however, I do believe I was told to stop taking multi-vitamins for a time before surgery. You may have received this information at your preoperative physical exam in the POE clinic. The capsules should be taken with food and should not be crushed, chewed, or cut in half. But when his 72-year-old wife, Fish oil is a great source of the omega-3 fatty acids we all need for, Omega-3 fish oil certainly has a reputation for delivering a plethora of incredible benefits. Copyright 1996-2023 Cerner Multum, Inc. More common side effects in people taking Vascepa to lower the risk of cardiovascular problems include: muscle or bone pain. It is unclear how Vascepa helps decrease your risk of heart problems outside of lowering your triglyceride levels. For context, that would be the same as swallowing almost cup of Omega Cure fish oil, or taking 33 regular fish oil capsules daily, which is significantly more omega-3 than any patient needs to take. This is sometimes referred to as being optimized for surgery. Vascepa only contains eicosapentaenoic acid (EPA), whereas most other fish oils (including prescription fish oils) contain both EPA and docosahexaenoic acid (DHA). . Sometimes, it should be stopped 48 hours before and 48 hours after surgery to decrease the risk of a problem called lactic acidosis. In the medical community today, theres excitement that omega-3 fatty acids may actually reduce the risk of infections and complications post-surgery. Adprin-B products. Stop 2 days before surgery; Creatinine Clearance . In those with atherosclerotic cardiovascular disease (ASCVD), the risk of events decreased by 35% after 4.9 years. Your liver makes very low-density lipoprotein (VLDL) triglycerides, which increases the amount of triglycerides in your blood. Dont take more Vascepa than your doctor prescribes. Liver problems. Medications to Avoid Before Surgery Some medications contain aspirin and/or have effects that may cause more bleeding and bruising. Always consult your healthcare provider first. Scientific Reports, 5, 11276. If you are going home the same day, you may return to the preoperative area. New studies, however, have extensively documented that taking omega-3 supplements before operations not only appears to be safe, but may even be highly beneficial. Some supplements, such as feverfew, ginkgo, garlic, ginseng, and Dong Quai can also increase a persons bleeding risk. For more on that, read Fresh Fish Oil: Why It Matters to Your Health.. Please discuss with your surgeon. If you do, your surgery may be canceled or postponed. The risk of blood clots has been associated with synthetic hormone formulations which is why your doctor will tell you to stop taking your hormones before surgery. And they want you to get the best care possible. Report of the National Lipid Associations Safety Task Force: The Nonstatins. Vascepa is a prescription omega-3 fatty acid that is similar to fish oil but not exactly the same. In addition, studies indicate that omega-3s could potentially improve microbiome health, regulate constipation, ease anxiety, and reduce the need for excessive painkillers all common concerns for surgical patients. glycoprotein platelet inhibitors such as abciximab or tirofiban, NSAIDs, such as ibuprofen, diclofenac, etodolac, and naproxen. Follow your doctor's instructions very closely. eGmwUaP6-EU Last updated on Feb 22, 2023. A nurse or care team member will call a few days before your surgery with information about your procedure, what you can eat or drink, visitor guidelines and how to be notified of your arrival time for surgery. After check-in, you are taken to a preoperative area, where a member of your care team will gather information like your health history and vital signs. Irritability or mood disturbances. If youre breastfeeding or considering breastfeeding, tell your doctor before starting Vascepa. Ask them what other medications are better options for you. Also, if youre having trouble opening your medication bottles, let your pharmacist know. A list of materials or medications that you are allergic to or that have caused adverse reactions, such as latex or iodine. Strengthen your lungs. Be sure to follow your doctors instructions. Some medications interact with alcohol, though Vascepa is not one of them. The U.S. Food and Drug Administration today approved the use of Vascepa (icosapent ethyl) as an adjunctive (secondary) therapy to reduce the risk of cardiovascular events among adults with. It is unknown if people with allergies to fish or shellfish have an increased risk of allergy with Vascepa. Understanding how this drug may treat your condition will help you decide whether its a good option for you. Dr. Chalmers practiced medicine for many years, serving both at high-tech hospitals and as a community health worker in rural Norway. Therapies including fish oil, probiotics, siRNA, Elevated triglyceride levels are linked with increased risk of certain conditions. Most patients stay here for at least two hours after their surgery is complete. Get emergency medical help if you have signs of an allergic reaction to Vascepa: hives; difficult breathing; swelling of your face, lips, tongue, or throat. May be used in addition to statin therapy to reduce the risk of a heart attack, stroke, coronary revascularization, and unstable angina that may require admission to hospital in adults with high triglyceride levels ( 150 mg/dL) and established cardiovascular disease. Vascepa can interact with several kinds of drugs. The safety of Vascepa in children has not been established. Youll take 4 gm of Vascepa per day. Because of the blood-thinning drug he took to prevent strokes, it would be hard for his blood to coagulate and stop the flow. But it can block platelets, a kind of blood cell, from bunching up in your blood. Vascepa is the only prescription omega-3 approved for cardiovascular risk reduction alongside diet modification. Omega-3 Polyunsaturated Fatty Acids in the Prevention of Postoperative Complications in Colorectal Cancer: A Meta-Analysis. Tell your doctor if you are also using aspirin, clopidogrel, or a blood thinner (including warfarin). Using fish oil, however, can help to lubricate the intestinal tract, allowing for easier bowel movements. Generally, a physical exam is not required for patients who are scheduled for a low-risk surgical procedure; are not taking any prescriptions; and don't have chronic health conditions, like high blood pressure, diabetes, obesity or heart disease. Drug class: Miscellaneous antihyperlipidemic agents. should i stop vascepa before surgery. The. If you take too much Vascepa, your doctor may closely monitor you for signs and symptoms of overdose. We strongly recommend stopping these drugs five to seven days before surgery to reduce your risk of bleeding, but discussion with your cardiologist and surgeon is advised. Before initiating Vascepa, assess the person's lipid levels and try to identify other causes of high triglycerides such as diabetes, hypothyroidism, or medications and manage as appropriate. 3. 9m|ZSImU8;Si?j :X_5M`U[!4G!GwZ^C'CC[x -_ZV2h(/\$kQ7? In some people, hair loss may be due to a medical condition, another medication, diet or stress levels. Fish oil supplements are usually safe but may not benefit everyone. Follow your diet, medication, and exercise routines very closely. To make sure Vascepa is safe for you, tell your doctor if you have ever had: liver disease; diabetes; a thyroid disorder; problems with your pancreas; a bleeding or blood-clotting disorder; or if you are allergic to fish or shellfish. Care team members will monitor your vital signs, alertness, pain or discomfort, and the need for medications. In addition, fish oil also diminishes the amount of pro-inflammatory endotoxins produced by harmful bacteria (10). The review concluded that the risk of problematic bleeding was virtually nonexistent, even when combined with other medications known to increase the risk of bleeding (1). These werent reported side effects in studies of Vascepa. should i stop vascepa before surgery. As a result, such supplements may also contain certain toxins found in fish. Akintoye, E., Sethi, P., Harris, W.S., et al. Nandivada, P. et al. This allows us to use effective medications to control your pain after surgery. Forget HDL and LDL. The median change in triglycerides from baseline in the Vascepa group after one year was -39 mg/dL (or a drop of 18%) and 5 mg/dL in the placebo group (an increase of 2%). However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Drug class: miscellaneous antihyperlipidemic agents. 12. Key takeaways: Aspirin is an important daily medication for a lot of people. Correia, M. et al. Both aspirin and Vascepa may increase your risk of bleeding, so taking them together further increases this risk. Avoid white bread, white rice, chips, and sugar-laden foods and drinks. Is It Good to Store Fish Oil in the Freezer? Uses: Patients should engage in appropriate nutritional intake and physical activity before receiving VASCEPA, which should continue during treatment with VASCEPA. Slip-on walking shoes or nonskid slippers. So, you should stop smoking weeks before any scheduled surgery and inform your doctor of your habit of smoking occasionally, weekly, or daily. Arrange support from family or friends during and after surgery, including transportation to and from the hospital. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Docosahexaenoic Acid Inhibits Helicobacter Pylori Growth In Vitro and Mice Gastric Mucosa Colonization. It's important to have a healthy lifestyle before starting Lovaza or Vascepa. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It also could identify problems or issues that may complicate or delay your planned surgery. It is unclear how Vascepa works for this purpose. Continue reading, Hair thinning or loss (alopecia) is not listed as a side effect in data reviewed by the FDA for the approval of Vascepa. But drinking too much alcohol can increase triglycerides. If you have allergies to fish or shellfish, tell your doctor before taking Vascepa. 2. 7. If you need to take both drugs, your doctor will check you for bleeding during Vascepa treatment. 2. Having too many triglycerides in your blood can be harmful and lead to heart disease. Yes, in some cases, Lovaza may be used as an alternative to Vascepa. Another review from 2008 similarly found that no published studies had reported clinically significant bleeding episodes among patients treated with antiplatelet drugs and fish oil at doses ranging from 3 to 7g every day (2). The exam gives your surgeon and anesthesiology team important information about your health so they are prepared and can tailor your surgical care to your specific medical needs. Quit smoking. You will wait in this area until the operating or procedure room is available. In animal studies, there were no clinically relevant adverse developmental effects noted when rabbits were given the equivalent of 5 times the recommended dose. Laboratory results showed that Vascepa reduced triglycerides by a median of -39 mg/dL (or a drop of 18%) after one year whereas those assigned to placebo had an increase in triglycerides of 5 mg/dL (an increase of 2%). Items to help pass the time while you wait, such as a book, music, phone or magazine. The results? By only containing EPA, Vascepa reduces high triglycerides without raising levels of bad cholesterol or LDL-C. Vascepa is also a lot stronger than most over-the-counter (OTC) fish oils (up to four times the strength). Follow all directions carefully. Your doctor can also tell you about other treatments you can use for your condition. A healthy diet low in sugar, alcohol, and unhealthy fats can help lower triglycerides. Understand exactly what surgery is planned, along with the risks, benefits, and other options. Your pharmacist may also recommend tools to help make it simpler to open the drugs container. An increase in liver enzymes may signal that your liver function is getting worse. If. This is not a complete list of side effects and others may occur. Fish Oil LC-PUFAs Do Not Affect Blood Coagulation Parameters and Bleeding Manifestations: Analysis of 8 Clinical Studies with Selected Patient Groups on Omega-3-Enriched Medical Nutrition. Aspirin (Anacin, Ascriptin, Bayer, Bufferin, Ecotrin, Excedrin), Choline and magnesium salicylates (CMT, Tricosal, Trilisate), Diclofenac sodium (Voltaren, Voltaren XR), Diclofenac sodium with misoprostol (Arthrotec), Ibuprofen (Advil, Motrin, Motrin IB, Nuprin), Ketoprofen (Actron, Orudis, Orudis KT, Oruvail), Magnesium salicylate (Arthritab, Bayer Select, Doan's Pills, Magan, Mobidin, Mobogesic), Salsalate (Amigesic, Anaflex 750, Disalcid, Marthritic, Mono-Gesic, Salflex, Salsitab). And as the above research demonstrates, consuming omega-3s from fish oil prior to surgery is similarly safe, unless a person has a bleeding disorder or is on lots of blood thinning medications. If you think your liver function is getting worse, talk with your doctor immediately. Check the label on the medicine for exact dosing instructions. Youll take Vascepa capsules by mouth twice per day with food. In people with liver disease, monitor levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels regularly during Vascepa treatment. You should also be following a healthy lifestylesuch as getting moderate exercise and following a healthy dietbefore and while taking Vascepa. If youre concerned about weight loss or hair loss during Vascepa treatment, talk with your doctor or pharmacist. In a 2017 review, another group of researchers similarly discovered that omega-3 supplementation reduced the length of hospital stays, as well as the risk of atrial fibrillation (6). Last updated on Feb 17, 2022. Vascepa can increase the risk of bleeding (thin the blood). Vascepa is also associated with an increased risk of atrial fibrillation or atrial flutter requiring hospitalization (occurs in 3% of patients taking Vascepa compared with 2% of those taking placebo). Anacin products. Today, she serves as the president of Omega3 Innovations. The usual dosage is 4 grams per day taken as either four 0.5 gram capsules twice daily with food or as two 1 gram capsules twice daily with food. Studies also show that omega-3 fish oil intake is also useful in avoiding one of the biggest post-surgical complications: constipation. Revision date: May 11, 2022. Prescription Omega 3 (Lovaza, Vascepa) ***** Commonly used over-the-counter medications that are blood thinners. Call your doctor if you think youve taken too much Vascepa. Your doctor may ask you to take Vascepa with a statin, a drug that helps decrease cholesterol. So, dont be afraid to ask questions or offer feedback on your treatment. TNF agents) lowers the risk of, Agents are stopped 1-2 weeks before procedure and resumed 2-4 weeks after surgery, Consult with orthopedics and rheumatology regarding specific medications and patient risk factors, Safest overall strategy due to numerous combination products, Specific agents with known risk in the perioperative period, Gingko (discontinue at least 36 hours before surgery), Danielson (2012) ICSI: Preoperative Evaluation. should i stop vascepa before surgeryannick goutal vanille exquise. In addition, Vascepa is not used to treat pancreatitis, which is an inflammation of the pancreas that can be caused by high triglycerides. For more information about how Vascepa compares with fish oil, see this article. Risk of Post-Procedural Bleeding in Children on Intravenous Fish Oil. You may even feel anxious, confused or scared. This decreases triglyceride levels in the body. In the REDUCE-IT trial, Vascepa significantly reduced the risk of cardiovascular events, such as cardiovascular death, heart attack, stroke, coronary revascularization, or hospitalization for unstable angina by about 25% after approximately 4.9 years. Drug class: miscellaneous antihyperlipidemic agents. (2017). One trial showed that 12% of people receiving Vascepa experienced a bleeding event and in 3% of people, this bleeding event was severe. Studies show that omega-3 fatty acids improve the ratio of beneficial to harmful bacteria, as well as diminish the ability of harmful bacteria to colonize the stomach (8, 9). Talk with your cardiologist (heart doctor) before you stop taking any aspirin product or clopidogrel (Plavix). If you have allergies to fish or shellfish, tell your doctor before taking Vascepa. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Fish Oils and Bleeding: Is There a Clinically Significant Risk? Many surgeries are scheduled for the early morning. In recent years, researchers have also started to look at the microbiomes influence on the immune system. Aspirin. Medicines that interact with Vascepa may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Vascepa. Importance of Maintaining a Low Omega-6/Omega-3 Ratio for Reducing Inflammation. * To learn more about this side effect, see the Allergic reaction section below. May be given in addition to diet to adults with extremely high triglyceride levels ( 500 mg/dL) in addition to dietary changes aimed at reducing cholesterol intake. Move every day. June 29, 2022; creative careers quiz; ken thompson net worth unix . There is also more data to support the effectiveness and safety of prescription-strength fish oils compared with OTC varieties. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. So what does that mean for patients and their recovery? You need to stop your anti-coagulation medications before your colonoscopy. If you do experience an allergic reaction after taking Vascepa, discontinue it immediately, and seek immediate medical attention. These factors include what your insurance plan covers and which pharmacy you use. Laboratory results showed that the average starting levels of triglycerides and LDL-C were similar between the Vascepa and placebo groups, but after one year of taking Vascepa, there was a significant difference between these values between the two groups.
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